Over at Lifehacker.com (I swear, I spend way too much time there ) they have a great post detailing how to setup your system to use OpenDNS.

However, if you use Windows Home Server or the likes please be aware that this may cause internal network-issues. To get around these,  either use an internal DNS-server where all your machines register (advanced setup) or setup static DNS entries in your DNS-tab of your router (simpler)

I recommend setting up OpenDNS servers only on your router, and not on your home-PC’s. This way you can ’solve’ the above issue by just using a local DNS-entry / static mapping in your router to have your network working normally - albeit protected from the DNS vulnerability.

On top of that OpenDNS is really fast and good. And I use it to block miscellaneous stuff, such as phishing-sites and more (free registration required though)